Tau fibrils evade autophagy by excessive p62 coating and TAX1BP1

p62 app  macular degeneration and cancer in animals, and the possible application of p62 plasmid in other inflammation-associated diseases  Here we show that increasing brain p62 expression rescues cognitive deficits in APPPS1 mice, a widely used animal model of AD

p62 ΔPB1, mCherry p62 ΔPB1 ΔUBA, or mCherry p62 ΔPB1 S403E The neuroprotective role of Panax notoginseng saponins in APPPS1 transgenic mice This review focuses on the role of p62 in linking the ubiquitin–proteasome system and autophagy pathway upon ubiquitinated protein degradation

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